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POLR2G

Description

RNA polymerase II subunit G

Summary

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

Location

11q12.3

External Links
GeneCards , NCBI

Executive summary

  • POLR2G was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • POLR2G was a six-sigma dependency in 6 cell lines.
  • No significant models found for POLR2G

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to POLR2G's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for POLR2G

Biomarkers for dependency on POLR2G (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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