PPP1CB

Description

protein phosphatase 1 catalytic subunit beta

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Location

2p23.2

External Links
GeneCards , NCBI

Executive summary

  • PPP1CB was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 8 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for PPP1CB which had an out-of-bag R^2 of 0.18 (FDR 3.84e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to PPP1CB's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for PPP1CB

Biomarkers for dependency on PPP1CB (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol