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PPP1R3B

Description

protein phosphatase 1 regulatory subunit 3B

Summary

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

Location

8p23.1

External Links
GeneCards , NCBI

Executive summary

  • PPP1R3B was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 12 shRNAs.
  • No significant models found for PPP1R3B

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to PPP1R3B's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for PPP1R3B

Biomarkers for dependency on PPP1R3B (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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