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ribosomal protein L21

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

13q12.2

GeneCards , NCBI

Executive summary

RPL21 was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 5 shRNAs.
RPL21 was a six-sigma dependency in 1 cell lines.
The search for "Related features" MDPs resulted in the most predictive model for RPL21 which had an out-of-bag R^2 of 0.23 (FDR 2.11e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features", "CYCLOPS".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to RPL21's dependency profile

Table genes' correlated

Correlated gene dependency	Correlation (r)	Z_score

Correlation graph for RPL21

Biomarkers for dependency on RPL21 (ATLANTIS)

Context	Dependency dataset	Biomarker types	Biomarker subset	Score transform	Top biomarker	R^2	P-Value	FDR	Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID	Gene Symbol	Seed1 Sequence	Seed2 Sequence	Gene Rsquared	Seed1 Rsquared	Seed2 Rsquared	Seeds Rsquared	Other Gene Rsquared	Total Rsquared	Alpha1	Alpha2	Beta	Other Gene Symbol

RPL21

Executive summary

Dependency profile

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Scatterplot Dependency vs Copy Number

Gene's correlated to RPL21's dependency profile

Table genes' correlated

Correlation graph for RPL21

Biomarkers for dependency on RPL21 (ATLANTIS)

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

98k shRNA library (v2.19.2)

ShRNA Quality

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