RPS21

Description

ribosomal protein S21

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Location

20q13.33

External Links
GeneCards , NCBI

Executive summary

  • RPS21 was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for RPS21 which had an out-of-bag R^2 of 0.22 (FDR 2.27e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to RPS21's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for RPS21

Biomarkers for dependency on RPS21 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol