succinate dehydrogenase complex flavoprotein subunit A
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
SDHA was screened in 216 cell
lines with 9 shRNAs, and 285 cell
lines with 9 shRNAs.
The search for "Unbiased" MDPs resulted in the most predictive model for SDHA which had an out-of-bag R^2 of
0.34 (FDR 2.81e-02).
In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "CYCLOPS".