DepMap - Broad Institute

Home Contact us

Home

splicing factor 3b subunit 1

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

2q33.1

GeneCards , NCBI

Executive summary

SF3B1 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 6 shRNAs.
SF3B1 was a six-sigma dependency in 1 cell lines.
The search for "Unbiased" MDPs resulted in the most predictive model for SF3B1 which had an out-of-bag R^2 of 0.28 (FDR 3.48e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "CYCLOPS".

Dependency profile

Loading graph

Download

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Placeholder while we fetch the data

Loading graph

Scatterplot Dependency vs Copy Number

Placeholder while we fetch the data

Loading graph

Gene's correlated to SF3B1's dependency profile

Table genes' correlated

Correlated gene dependency	Correlation (r)	Z_score

Correlation graph for SF3B1

Biomarkers for dependency on SF3B1 (ATLANTIS)

Context	Dependency dataset	Biomarker types	Biomarker subset	Score transform	Top biomarker	R^2	P-Value	FDR	Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

Loading graph

98k shRNA library (v2.19.2)

Loading graph

ShRNA Quality

shRNA ID	Gene Symbol	Seed1 Sequence	Seed2 Sequence	Gene Rsquared	Seed1 Rsquared	Seed2 Rsquared	Seeds Rsquared	Other Gene Rsquared	Total Rsquared	Alpha1	Alpha2	Beta	Other Gene Symbol

SF3B1

Executive summary

Dependency profile

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Scatterplot Dependency vs Copy Number

Gene's correlated to SF3B1's dependency profile

Table genes' correlated

Correlation graph for SF3B1

Biomarkers for dependency on SF3B1 (ATLANTIS)

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

98k shRNA library (v2.19.2)

ShRNA Quality

About

Website built by Cancer Data Science - Broad Institute of MIT and Harvard