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SLU7

Description

SLU7 homolog, splicing factor

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008]

Location

5q33.3

External Links
GeneCards , NCBI

Executive summary

  • SLU7 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • SLU7 was a six-sigma dependency in 1 cell lines.
  • The search for "Unbiased" MDPs resulted in the most predictive model for SLU7 which had an out-of-bag R^2 of 0.27 (FDR 3.93e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "CYCLOPS".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to SLU7's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for SLU7

Biomarkers for dependency on SLU7 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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