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SPTLC2

Description

serine palmitoyltransferase long chain base subunit 2

Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]

Location

14q24.3

External Links
GeneCards , NCBI

Executive summary

  • SPTLC2 was screened in 216 cell lines with 6 shRNAs, and 285 cell lines with 6 shRNAs.
  • No significant models found for SPTLC2
  • SPTLC2 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to SPTLC2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for SPTLC2

Biomarkers for dependency on SPTLC2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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