SRSF3

Description

serine and arginine rich splicing factor 3

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

Location

6p21.31-p21.2

External Links
GeneCards , NCBI

Executive summary

  • SRSF3 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • SRSF3 was a six-sigma dependency in 25 cell lines.
  • The search for "Unbiased" MDPs resulted in the most predictive model for SRSF3 which had an out-of-bag R^2 of 0.33 (FDR 2.88e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to SRSF3's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for SRSF3

Biomarkers for dependency on SRSF3 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol