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TFRC

Description

transferrin receptor

Summary

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Location

3q29

External Links
GeneCards , NCBI

Executive summary

  • TFRC was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 4 shRNAs.
  • TFRC was a six-sigma dependency in 13 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for TFRC which had an out-of-bag R^2 of 0.14 (FDR 4.84e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".
  • TFRC was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to TFRC's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for TFRC

Biomarkers for dependency on TFRC (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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