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TMED10

Description

transmembrane p24 trafficking protein 10

Summary

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Location

14q24.3

External Links
GeneCards , NCBI

Executive summary

  • TMED10 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • No significant models found for TMED10

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to TMED10's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for TMED10

Biomarkers for dependency on TMED10 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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