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TOMM40

Description

translocase of outer mitochondrial membrane 40

Summary

The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]

Location

19q13.32

External Links
GeneCards , NCBI

Executive summary

  • TOMM40 was screened in 216 cell lines with 3 shRNAs, and 285 cell lines with 5 shRNAs.
  • TOMM40 was a six-sigma dependency in 14 cell lines.
  • No significant models found for TOMM40

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to TOMM40's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for TOMM40

Biomarkers for dependency on TOMM40 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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