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UBR4

Description

ubiquitin protein ligase E3 component n-recognin 4

Summary

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

Location

1p36.13

External Links
GeneCards , NCBI

Executive summary

  • UBR4 was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 5 shRNAs.
  • UBR4 was a six-sigma dependency in 12 cell lines.
  • No significant models found for UBR4

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to UBR4's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for UBR4

Biomarkers for dependency on UBR4 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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