DepMap - Broad Institute

ubiquitin specific peptidase 39

None

2p11.2

GeneCards , NCBI

Executive summary

USP39 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
The search for "Unbiased" MDPs resulted in the most predictive model for USP39 which had an out-of-bag R^2 of 0.21 (FDR 4.95e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "CYCLOPS".
USP39 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to USP39's dependency profile

Table genes' correlated

Correlated gene dependency	Correlation (r)	Z_score

Correlation graph for USP39

Biomarkers for dependency on USP39 (ATLANTIS)

Context	Dependency dataset	Biomarker types	Biomarker subset	Score transform	Top biomarker	R^2	P-Value	FDR	Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID	Gene Symbol	Seed1 Sequence	Seed2 Sequence	Gene Rsquared	Seed1 Rsquared	Seed2 Rsquared	Seeds Rsquared	Other Gene Rsquared	Total Rsquared	Alpha1	Alpha2	Beta	Other Gene Symbol