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VARS

Description

valyl-tRNA synthetase

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

Location

6p21.33

External Links
GeneCards , NCBI

Executive summary

  • VARS was screened in 216 cell lines with 3 shRNAs, and 285 cell lines with 3 shRNAs.
  • VARS was a six-sigma dependency in 2 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for VARS which had an out-of-bag R^2 of 0.18 (FDR 3.60e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".
  • VARS was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to VARS's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for VARS

Biomarkers for dependency on VARS (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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