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ZEB2

Description

zinc finger E-box binding homeobox 2

Summary

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

Location

2q22.3

External Links
GeneCards , NCBI

Executive summary

  • ZEB2 was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 5 shRNAs.
  • ZEB2 was a six-sigma dependency in 10 cell lines.
  • The search for "Expression driven" MDPs resulted in the most predictive model for ZEB2 which had an out-of-bag R^2 of 0.47 (FDR 2.72e-03). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "Expression driven".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to ZEB2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for ZEB2

Biomarkers for dependency on ZEB2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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