Updates and Announcements

26Q1 - Portal update

The 26Q1 release is now available! Please read the release notes for more details on new data and pipeline updates.

Release Highlights

• 25 new genome-wide CRISPR screens and Omics for Adult and Pediatric models
• Subtype tree updates for CNS models (October 9, 2025 OncoTree update)
• Updates to CRISPR pipeline for library correction
• Updates to Mutation pipeline for variant filtering and hotspots
• Context Manager update to allow for all metadata types to be used when defining contexts
• New Tool! GeneTEA uses natural language processing to uncover biology across the portal

HCMI TPM dataset

We have added 591 models and 298 tumors from the Human Cancer Models Initiative (HCMI) into our Celligner visualization, using RNA-seq TPM quantifications from NCI’s Genomic Data Commons (GDC).

Olink Proteomics dataset

We have profiled 161 cell lines covering 24 different cell line lineages using the Olink Explore HT platform. To learn more about Olink, please visit their website here.

Sanger Proteomics dataset

We’ve included a matrix of relative protein quantities from Gonçalves et al. 2022. The original data was downloaded from Cell Model Passports.

Read the full Release Notes