Explore the Cancer Dependency Map
Welcome to the DepMap Portal!
The goal of the Dependency Map (DepMap) portal is to empower the research community to make discoveries related to cancer vulnerabilities by providing open access to key cancer dependencies analytical and visualization tools.Use this portal to:
DISCOVER genetic and pharmacological dependencies
PRIORITIZE tumor contexts and predictive biomarkers
Explore the relationship between MTAP expression and PRMT5 dependency
EXPLORE over 2000 cancer models
BROWSE and download the latest datasets
Visit the DepMap Community Forum to ask questions, report issues and share your suggestions.
Call for Cancer Cell Models
We wouldn’t be able to build DepMap without the help of the many collaborators and partners who have already shared their cell lines and organoids.If you are interested in identifying cancer vulnerabilities in your favorite models, please consider sharing them and allowing us to generate data which will be available to the entire community.
Announcements
Please note that the 20Q3 omics datasets are identical to what was released in 20Q2. There is no new omics data for this quarter, please check back in 20Q4!
We are very excited to announce the new DepMap Community Forum! Here you can ask DepMap questions or provide your thoughts and suggestions about the data and analyses being presented on the portal. Test it out and let us know what you think.
Data Explorer now includes the Custom Analysis tool for performing two-class comparisons or computing Pearson correlation across all features in a dataset.
You can now download subsets of datasets by cell lines, genes, and compounds. Check it out under Custom Downloads.
Find cell lines that most closely resemble a tumor type of interest with the new Celligner tool.
Gene pages now have a new enrichment figure that will show sublineage information.
New features and data updated quarterly
This portal enables analysis of data generated at the Broad Institute jointly with data generated elsewhere including:
- Omics data from the Cancer Cell Line Encyclopedia (CCLE)
- Gene dependency data from Broad’s Project Achilles
- Small-molecule sensitivity data from Broad’s PRISM Repurposing
- Novartis’ Project DRIVE
- Sanger’s Project Score
- Sanger’s GDSC
- Broad’s CTD2
- Quantitative proteomics from the Gygi lab
As part of our commitment to Open Science, we make all the Broad Institute data generated by the DepMap Project rapidly available to the public under the permissive CC BY 4.0 license on a quarterly basis and prepublication.
Because this portal also hosts data not generated by the Broad Institute DepMap Project, please be sure to review the data policy for each dataset prior to use.
