Explore the Cancer Dependency Map
Welcome to the DepMap Portal!
The goal of the Dependency Map (DepMap) portal is to empower the research community to make discoveries related to cancer vulnerabilities by providing open access to key cancer dependencies analytical and visualization tools.Use this portal to:
DISCOVER genetic and pharmacological dependencies
PRIORITIZE tumor contexts and predictive biomarkers
Explore the relationship between MTAP expression and PRMT5 dependency
EXPLORE over 2000 cancer models
BROWSE and download the latest datasets
Share your comments, request features or report a bug on the DepMap Community Forum
Call for Cancer Cell Models
We wouldn’t be able to build DepMap without the help of the many collaborators and partners who have already shared their cell lines and organoids.If you are interested in identifying cancer vulnerabilities in your favorite models, please consider sharing them and allowing us to generate data which will be available to the entire community.
Announcements
Gene pages now have a new enrichment figure that will show sublineage information.
Want tips on how to think about DepMap data? Interested in knowing more about the decisions that go into the portal? CDS is launching its official blog to address this and more. Check it out at https://cancerdatascience.org/blog/.
Proteome data now available for download and integrated in portal tools.
Drug Repurposing data from Corsello, Nature Cancer (2020) now out, and fully incorporated in Data Explorer and explorable on the Dose Curves tab! Download the data here or explore the data on the paper landing page
New features and data updated quarterly
This portal enables analysis of data generated at the Broad Institute jointly with data generated elsewhere including:
- Omics data from the Cancer Cell Line Encyclopedia (CCLE)
- Gene dependency data from Broad’s Project Achilles
- Small-molecule sensitivity data from Broad’s PRISM Repurposing
- Novartis’ Project DRIVE
- Sanger’s Project Score
- Sanger’s GDSC
- Broad’s CTD2
- Quantitative proteomics from the Gygi lab
As part of our commitment to Open Science, we make all the Broad Institute data generated by the DepMap Project rapidly available to the public under the permissive CC BY 4.0 license on a quarterly basis and prepublication.
Because this portal also hosts data not generated by the Broad Institute DepMap Project, please be sure to review the data policy for each dataset prior to use.
