Welcome to the DepMap Portal!
The goal of the Dependency Map (DepMap) portal is to enable the research community to make discoveries related to cancer vulnerabilities by providing free and timely access to the datasets, visualizations, and analysis tools that are being used by the Cancer Dependency Map Project at the Broad Institute.
The goal of the Cancer Dependency Map Project is to systematically catalog and identify biomarkers of genetic vulnerabilities and drug sensitivities in hundreds of cancer models and tumors, to accelerate the development of precision treatments. Read more about it here.
As part of our commitment to Open Science, we make all the data generated by the DepMap Project rapidly available to the public under the permissive CC BY 4.0 license on a quarterly basis and pre-publication. Because this portal also hosts data not generated by the DepMap Project, please be sure to review the data policy for each dataset prior to use. New features are added to the portal quarterly as well.
This portal provides easy access to harmonized data created at the Broad Institute and elsewhere, including:
- Omics data from the Cancer Cell Line Encyclopedia (CCLE)
- Genetic dependency data from Broad’s Project Achilles
- Small-molecule sensitivity data from Broad’s PRISM Repurposing
- Novartis’ Project DRIVE
- Sanger’s Project Score
- Sanger’s GDSC
- Broad’s CTD2
The portal is being developed by the Cancer Data Science group in collaboration with the DepMap team at the Cancer Program of the Broad Institute of Harvard and MIT.
Share your comments, request features or just show your love — contact us at firstname.lastname@example.org.
Use this portal to:
UNDERSTAND Dependency profiles at genome-scale across more than 500 human cell lines
FIND Detailed genetic and pharmacologic characterization of over 1000 cell lines
IDENTIFY Genetic drivers that have functional importance as potential drug targets
SEARCH For cell line models that best represent your research interests
EXPORT Presentation-quality figures
The Public 19Q3 copy number file has been amended to have the log2 transform correctly applied to it. In addition, some duplicate cell lines were removed. This new version is named CCLE_gene_cn_v3.csv, and can be found here.
A new version of the CCLE_gene_cn file can be found here.
New drug data for the PRISM Repurposing Primary Screen now out! Data for 4,686 compounds screened against 578 cell lines can be found here.
A new Portal FAQ can be found here.
Expression, fusion, and copy number are now all called from hg38 realigned bams
Cell line star-ing has been upgraded to save multiple lists! Lists can be applied to data explorer and gene/compound pages to highlight your favorite cell lines as stars. Previously saved cell lines should be automatically imported upon opening Tools -> Cell Line Selector.
CERES-processed Sanger Project Score CRISPR data is now available on gene pages, as well as for download on the Downloads page