August 6, 2018
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The goal of the Cancer Dependency Map is to create a comprehensive preclinical reference map connecting tumor features with tumor dependencies to accelerate the development of precision treatments. Our strategy is to systematically characterize cellular models of cancers and to test those models for sensitivity to genetic and small-molecule perturbations. By integrating data beyond those collected at the Broad, DepMap hopes to develop a complete understanding of the vulnerabilities of cancer, identify targets for therapeutic development, and design strategies to optimize patient responses to those therapies.



To date DepMap has profiled more than 500 cell lines. Over the next several years we will greatly expand the diversity of cell lines profiled for genetic vulnerabilities with quarterly data release. Additionally, limited drug sensitivity data are available.