Feb 6, 2019
Feb 1, 2019
  • Updated pipelines used for expression, mutation, and copy number. See more details here.

  • Added CTD2 dose-level data. See dose-response curves on compound sensitivity pages by clicking on a cell line.


Look up dependencies

The goal of the Cancer Dependency Map is to create a comprehensive preclinical reference map connecting tumor features with tumor dependencies to accelerate the development of precision treatments. Our strategy is to systematically characterize cellular models of cancers and to test those models for sensitivity to genetic and small-molecule perturbations. By integrating data beyond those collected at the Broad, DepMap hopes to develop a complete understanding of the vulnerabilities of cancer, identify targets for therapeutic development, and design strategies to optimize patient responses to those therapies.

To date DepMap has profiled more than 500 cell lines. Over the next several years we will greatly expand the diversity of cell lines profiled for genetic vulnerabilities with quarterly data release. Additionally, limited drug sensitivity data are available.

We wouldn’t be able to build DepMap without the help of the many collaborators and partners who have already shared their cell lines. If you are interested in identifying cancer vulnerabilities in your favorite cell lines, please consider sharing your valuable cell line models and allowing us to generate data which will be available to the entire community.