24Q2 DepMap Data!

The 24Q2 release is now live and contains new cell lines and datasets, metadata and pipeline improvements. Please read the release notes for more details.

Fixed bug which caused some compound names to not show data from GDSC screens

The 23Q4 release is now live and contains new data, updates to portal tools, metadata and pipeline improvements. Please read the release notes for more details.

Bug fix: The "Peturbation Effects" tab of the gene page was not correctly coloring points for lines with hotspot or damaging mutations. This has been fixed.

We've added additional single point compound screening data from the PRISM Repurposing project to the portal. You can see it in the portal labeled, "PRISM Repurposing Public 23Q2" and is a superset of the data that was previously released as "Repurposing Primary"

We are excited to share new CRISPR and omics data, a Chronos update and a new Target Discovery app in this 23Q2 release! You’ll also notice an update to our cell line page. We hope this new format will allow users to more easily navigate the information presented for each cell line.

In this release, you will likely notice some changes in the data now that Chronos 2.0 integrated CRISPR data is being produced by a joint Chronos run. This change reduces the number of false positives in the integrated dataset by 5%. Please read the full announcement for more information.

Additionally, we are aware that there is an artifact in the CRISPR data which causes background correlation in dependency between genes located on the same chromosome arm. To account for this, we've aligned the mean gene effect of each chromosome arm to be the same in every cell line following the original copy number correction. Overall we see an improvement in data quality, as well as a reduction in clustering by chromosome arm in UMAP embeddings.

See more information about this release see this forum post describing the full set of changes.