	Cell Line	Primary Disease	Lineage

My Cell Lines Unrecognized Please delete unrecognized cell lines, find cell line(s) matches in table to add.

AZ-628

Overview
Sensitivity

Sensitive Cell Lines

AZ-628 (GDSC:29) Drug sensitivity AUC (Sanger)

AUC

Enriched Lineages

AZ-628 (GDSC:29) Drug sensitivity AUC (Sanger)

AUC

1. Melanoma (5.4e-07)
2. Skin (7.4e-06)
3. Leukemia (1.3e-05)
4. AML (2.3e-05)
5. CML (4.6e-04)

Enriched lineages have p-values < 0.0005 shown in parentheses.

Metadata from the repurposing hub

MOA: RAF inhibitor

Phase: Preclinical

Target: BRAF, RAF1

Choose dataset

AZ-628 (GDSC:29) Drug sensitivity AUC (Sanger)

AZ-628 (GDSC:29) Drug sensitivity IC50 (Sanger)

Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. Additionally, CTRP AUCs are not normalized by the dose range and thus have values greater than 1.