AZ-628

Sensitive Cell Lines

AZ-628 (BRD:BRD-K05804044-001-06-0) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 18/11 Public Tentative

53 cell lines shown


AUC


Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. View more


Enriched Lineages

AZ-628 (BRD:BRD-K05804044-001-06-0) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) 18/11 Public Tentative

AUC


Enriched lineages have p-values < 0.0005 (shown in parentheses). n= indicates the number of cell lines plotted in that lineage.


Top Correlated Expression

GenePearson correlation
Plot CCL3 0.57
Plot FAM131B 0.54
Plot TCEA1 0.51
Plot XPOT 0.50
Plot FRS2 0.50

All viability profiles for a given compound were correlated against all expression features. The highest correlated viability profile for each gene reported in the table above. Clicking 'plot' will visualize that comparison and show which dataset was used for the viability profile.

Datasets with data for AZ-628

DatasetCell LinesDose RangeAssay
GDSC1 987 1nM - 10μM Resazurin or Syto60
Repurposing Secondary 489 1nM - 10μM PRISM
Repurposing Primary 578 10μM PRISM


Metadata from the Repurposing Hub

MOA: RAF inhibitor
Phase: Preclinical
Target: BRAF, RAF1

Choose dataset

This symbol indicates that dose-level data is available for the dataset. Click on a point to view a dose curve.

Please note that AUC values depend on the dose range of the screen and are not comparable across different assays. Additionally, CTRP AUCs are not normalized by the dose range and thus have values greater than 1.