ARHGAP29

Rho GTPase activating protein 29

Dependent Cell Lines

CRISPR: 37/625 STRONGLY SELECTIVE

RNAi: 21/710 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Ovary (1.5e-07)
2. Ovary High Grade Serous (4.8e-07)
3. Ovary Adenocarcinoma (3.0e-06)
4. Melanoma (4.9e-05)
5. Skin (3.1e-04)

RNAi

Dependency Score (DEMETER2)

1. Ovary High Grade Serous (6.3e-07)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotPARD6B0.41
PlotPARD30.37
PlotPRKCI0.32
PlotCTNNA10.29
PlotPAX80.29

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotSPECC1L0.29
PlotCPLX20.29
PlotDCXR0.28
PlotAADACL20.27
PlotC16orf780.27

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Translocation

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Methylation (1kb upstream TSS) (1 94713316-94714316)

Methylation (1kb upstream TSS) (1 94703307-94704307)

CpG Methylation

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  • Official symbol: ARHGAP29
  • Full name: Rho GTPase activating protein 29
  • Location:
  • Also known as: PARG1
  • Entrez ID: 9411
  • Ensembl ID: ENSG00000137962

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