BRAF

B-Raf proto-oncogene, serine/threonine kinase

Dependent Cell Lines

CRISPR: 51/558 STRONGLY SELECTIVE

RNAi: 44/713 STRONGLY SELECTIVE


Dependency Score


Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (5.0e-59)
2. Skin (9.9e-48)


RNAi

Dependency Score (DEMETER2)

1. Melanoma (4.5e-46)
2. Skin (1.7e-44)
3. Colorectal (4.6e-05)
4. Thyroid (2.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number (log2 relative to ploidy)




Target Tractability



Mutations

# of Cell lines




Top Co-dependencies

CRISPR (Avana) Public 19Q1

GenePearson correlation
PlotMAPK10.66
PlotSOX100.56
PlotDUSP40.45
PlotMITF0.44
PlotSOX90.37

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMAPK10.56
PlotSOX100.45
PlotC8orf310.40
PlotPEA150.36
PlotMAP2K10.35


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Mutation Public 19Q1

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Translocation

Cell Line Map Id Break Point 1 Break Point 2 Trans Class Gene 1 Site 1 Gene 2 Site 2 Fusion Multi Sv Fusion Cosmic Fus

Methylation (1kb upstream TSS) (chr7 140624564-140625564)

CpG Methylation

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Protein Array (B-Raf_pS445)




  • Official symbol: BRAF
  • Full name: B-Raf proto-oncogene, serine/threonine kinase
  • Location:
  • Also known as: BRAF1
  • Entrez ID: 673
  • Ensembl ID: ENSG00000157764

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