BRAF

B-Raf proto-oncogene, serine/threonine kinase

Dependent Cell Lines

CRISPR: 50/563 STRONGLY SELECTIVE

RNAi: 44/713 STRONGLY SELECTIVE


Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Top Co-dependencies

CRISPR (Avana) Public 19Q2

GenePearson correlation
PlotMAPK10.66
PlotSOX100.59
PlotDUSP40.47
PlotMITF0.45
PlotMAP2K10.37

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMAPK10.56
PlotSOX100.45
PlotC8orf310.40
PlotPEA150.36
PlotMAP2K10.35

Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (5.0e-60)
2. Skin (2.0e-48)


RNAi

Dependency Score (DEMETER2)

1. Melanoma (4.5e-46)
2. Skin (1.7e-44)
3. Colorectal (4.6e-05)
4. Thyroid (2.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)




Target Tractability



Mutations

# of Cell lines





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Mutation Public 19Q2

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Translocation

Cell Line Map Id Break Point 1 Break Point 2 Trans Class Gene 1 Site 1 Gene 2 Site 2 Fusion Multi Sv Fusion Cosmic Fus

Methylation (1kb upstream TSS) (chr7 140624564-140625564)

Protein Array (B-Raf_pS445)




  • Official symbol: BRAF
  • Full name: B-Raf proto-oncogene, serine/threonine kinase
  • Location:
  • Also known as: BRAF1
  • Entrez ID: 673
  • Ensembl ID: ENSG00000157764

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