BRAF

B-Raf proto-oncogene, serine/threonine kinase

Dependent Cell Lines

CRISPR: 43/517 STRONGLY SELECTIVE

RNAi: 44/712 STRONGLY SELECTIVE


Dependency Score


Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (6.5e-54)
2. Skin (1.5e-48)


RNAi

Dependency Score (DEMETER2)

1. Melanoma (1.4e-46)
2. Skin (5.3e-45)
3. Colorectal (5.2e-05)
4. Thyroid (3.1e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number (log2 relative to ploidy)




Target Tractability



Mutations

# of Cell lines





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Mutation Public 18Q4

Cell Line Chr Start Position End Position Variant Classification Variant Type Reference Allele Tumor Seq Allele dbSNP ID Annotation Transcript Protein Change CCLE WES alt:ref CCLE WGS alt:ref CCLE RNAseq alt:ref Sanger WES alt:ref CCLE HC1650 alt:ref CCLE Raindance alt:ref ExAC Allelic Fraction TCGA Hotspot count

Translocation

Cell Line Break Point 1 Break Point 2 Trans Class Span Read Count Gene 1 Site 1 Gene 2 Site 2 Fusion

Fusion

Cell Line Fusion Name Left Gene Left Breakpoint Left Allelic Fraction Right Gene Right Breakpoint Right Allelic Fraction Junction Read Count Spanning Frag. Count Junction Read FFPM Spanning Frag. FFPM TCGA count GTEX count

CpG Methylation

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Protein Array (B-Raf_pS445)




  • Official symbol: BRAF
  • Full name: B-Raf proto-oncogene, serine/threonine kinase
  • Location:
  • Also known as: BRAF1
  • Entrez ID: 673
  • Ensembl ID: ENSG00000157764

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