ICE2

interactor of little elongation complex ELL subunit 2

Dependent Cell Lines

CRISPR: 421/625 COMMON ESSENTIAL

RNAi: 13/343

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Solid (1.8e-11)
2. Haematopoietic And Lymphoid (3.1e-11)
3. Leukemia (2.6e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotEAF10.47
PlotUSPL10.42
PlotTOE10.34
PlotELL0.34
PlotZNHIT30.31

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotELL0.43
PlotUSPL10.33
PlotZC3H80.31
PlotMED260.31
PlotRBM190.29

Target Tractability



Description

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  • Official symbol: ICE2
  • Full name: interactor of little elongation complex ELL subunit 2
  • Location:
  • Also known as: BRCC1, FLJ11896, NARG2
  • Entrez ID: 79664
  • Ensembl ID: ENSG00000128915

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