IDH3A

isocitrate dehydrogenase 3 (NAD(+)) alpha

Dependent Cell Lines

CRISPR: 182/625

RNAi: 20/708

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Glioma (3.7e-04)

RNAi

Dependency Score (DEMETER2)

1. Central Nervous System (5.2e-07)
2. Glioma (1.5e-06)
3. Glioblastoma (4.0e-06)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotACO20.33
PlotSLC25A30.30
PlotSLC4A70.29
PlotGMPS0.29
PlotTRPM70.27

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotVARS20.29
PlotC2orf76-0.26
PlotAPOC10.26
PlotIDH3B0.26
PlotMCCD10.26

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Methylation (1kb upstream TSS) (15 78440718-78441718)

CpG Methylation

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  • Official symbol: IDH3A
  • Full name: isocitrate dehydrogenase 3 (NAD(+)) alpha
  • Location:
  • Also known as:
  • Entrez ID: 3419
  • Ensembl ID: ENSG00000166411

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