NRAS

NRAS proto-oncogene, GTPase

Dependent Cell Lines

CRISPR: 47/625 STRONGLY SELECTIVE

RNAi: 31/712 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (8.2e-06)
2. Haematopoietic And Lymphoid (1.3e-04)
3. Solid (1.7e-04)
4. Skin (2.9e-04)
5. Multiple Myeloma (4.4e-04)

RNAi

Dependency Score (DEMETER2)

1. Solid (5.4e-06)
2. Leukemia (4.6e-05)
3. Glioma (2.0e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotRAF10.36
PlotSHOC20.36
PlotGRB2-0.30
PlotGOLGA70.30
PlotPTPN11-0.25

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotTOM10.36
PlotSHOC20.36
PlotCTSC0.33
PlotANKRD360.33
PlotMAP4K40.32

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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  • Official symbol: NRAS
  • Full name: NRAS proto-oncogene, GTPase
  • Location:
  • Also known as: N-ras
  • Entrez ID: 4893
  • Ensembl ID: ENSG00000213281

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