UBC

ubiquitin C

Dependent Cell Lines

CRISPR: 611/625 COMMON ESSENTIAL

RNAi: 368/711 STRONGLY SELECTIVE

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.
Strongly Selective: A gene whose dependency is at least 100 times more likely to have been sampled from a skewed distribution than a normal distribution (i.e. skewed-LRT value > 100).
Common Essential: A gene which, in a large, pan-cancer screen, ranks in the top X most depleting genes in at least 90% of cell lines. X is chosen empirically using the minimum of the distribution of gene ranks in their 90th percentile least depleting lines.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (2.7e-06)
2. Skin (8.8e-06)

RNAi

Dependency Score (DEMETER2)

1. Colorectal MSI (2.6e-06)
2. Ovary High Grade Serous (1.3e-05)
3. Colorectal (1.9e-04)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotHNRNPK0.33
PlotSNRPA10.29
PlotUSP140.29
PlotTCF250.27
PlotARCN10.27

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotPOLR2A0.38
PlotARMH40.32
PlotARMH40.32
PlotSH3D190.28
PlotSH3D190.28

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Fusion 19Q3

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Methylation (1kb upstream TSS) (12 125399587-125400587)

CpG Methylation

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  • Official symbol: UBC
  • Full name: ubiquitin C
  • Location:
  • Also known as:
  • Entrez ID: 7316
  • Ensembl ID: ENSG00000150991

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