Home
Contact us
Home

DHX9

Description

DExH-box helicase 9

Summary

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

Location

1q25.3

External Links
GeneCards , NCBI

Executive summary

  • DHX9 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 9 shRNAs.
  • DHX9 was a six-sigma dependency in 6 cell lines.
  • The search for "Related features" MDPs resulted in the most predictive model for DHX9 which had an out-of-bag R^2 of 0.15 (FDR 4.71e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".

Dependency profile

Histogram Table
Loading graph
Download

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Placeholder while we fetch the data
Loading graph

Scatterplot Dependency vs Copy Number

Placeholder while we fetch the data
Loading graph

Gene's correlated to DHX9's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for DHX9

Biomarkers for dependency on DHX9 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

Loading graph

98k shRNA library (v2.19.2)

Loading graph

ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

About

Contact Us

Website built by Cancer Data Science - Broad Institute of MIT and Harvard