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GPR37

Description

G protein-coupled receptor 37

Summary

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

Location

7q31.33

External Links
GeneCards , NCBI

Executive summary

  • GPR37 was screened in 216 cell lines with 4 shRNAs, and 285 cell lines with 7 shRNAs.
  • GPR37 was a six-sigma dependency in 2 cell lines.
  • No significant models found for GPR37
  • GPR37 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to GPR37's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for GPR37

Biomarkers for dependency on GPR37 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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