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RUVBL2

Description

RuvB like AAA ATPase 2

Summary

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

Location

19q13.33

External Links
GeneCards , NCBI

Executive summary

  • RUVBL2 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for RUVBL2 which had an out-of-bag R^2 of 0.17 (FDR 3.84e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to RUVBL2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for RUVBL2

Biomarkers for dependency on RUVBL2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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