SNRNP25

Description

small nuclear ribonucleoprotein U11/U12 subunit 25

Summary

Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

Location

16p13.3

External Links
GeneCards , NCBI

Executive summary

  • SNRNP25 was screened in 0 cell lines with 0 shRNAs, and 285 cell lines with 4 shRNAs.
  • SNRNP25 was a six-sigma dependency in 4 cell lines.
  • The search for "CYCLOPS" MDPs resulted in the most predictive model for SNRNP25 which had an out-of-bag R^2 of 0.14 (FDR 2.19e-02). In addition, this gene had a significant model when searching for the following MDPs: "CYCLOPS".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to SNRNP25's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for SNRNP25

Biomarkers for dependency on SNRNP25 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol