This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
SOD2 was screened in 216 cell
lines with 4 shRNAs, and 285 cell
lines with 6 shRNAs.
SOD2 was a six-sigma dependency in 4 cell lines.
The search for "Related features" MDPs resulted in the most predictive model for SOD2 which had an out-of-bag R^2 of
0.14 (FDR 4.99e-02).
In addition, this gene had a significant model when searching for the following MDPs: "Related features".