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TEA domain transcription factor 1

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

11p15.3

GeneCards , NCBI

Executive summary

TEAD1 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
TEAD1 was a six-sigma dependency in 25 cell lines.
The search for "Related features" MDPs resulted in the most predictive model for TEAD1 which had an out-of-bag R^2 of 0.24 (FDR 2.08e-02). In addition, this gene had a significant model when searching for the following MDPs: "Unbiased", "Related features", "Expression driven".

Dependency profile

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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to TEAD1's dependency profile

Table genes' correlated

Correlated gene dependency	Correlation (r)	Z_score

Correlation graph for TEAD1

Biomarkers for dependency on TEAD1 (ATLANTIS)

Context	Dependency dataset	Biomarker types	Biomarker subset	Score transform	Top biomarker	R^2	P-Value	FDR	Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

shRNA ID	Gene Symbol	Seed1 Sequence	Seed2 Sequence	Gene Rsquared	Seed1 Rsquared	Seed2 Rsquared	Seeds Rsquared	Other Gene Rsquared	Total Rsquared	Alpha1	Alpha2	Beta	Other Gene Symbol

TEAD1

Executive summary

Dependency profile

Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

Scatterplot Dependency vs Copy Number

Gene's correlated to TEAD1's dependency profile

Table genes' correlated

Correlation graph for TEAD1

Biomarkers for dependency on TEAD1 (ATLANTIS)

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

98k shRNA library (v2.19.2)

ShRNA Quality

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