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UQCRC2

Description

ubiquinol-cytochrome c reductase core protein II

Summary

The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]

Location

16p12.2

External Links
GeneCards , NCBI

Executive summary

  • UQCRC2 was screened in 216 cell lines with 5 shRNAs, and 285 cell lines with 5 shRNAs.
  • The search for "Related features" MDPs resulted in the most predictive model for UQCRC2 which had an out-of-bag R^2 of 0.16 (FDR 4.27e-02). In addition, this gene had a significant model when searching for the following MDPs: "Related features".
  • UQCRC2 was annotated as potentially druggable (either in DGIDB or IUPHAR/BPS Guide to PHARMACOLOGY).

Dependency profile

Histogram Table
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Scatterplots of dependency vs Expression/Copy Number

Scatterplot Dependency vs Expression

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Scatterplot Dependency vs Copy Number

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Gene's correlated to UQCRC2's dependency profile

Table genes' correlated

Correlated gene dependency Correlation (r) Z_score

Correlation graph for UQCRC2

Biomarkers for dependency on UQCRC2 (ATLANTIS)

Context Dependency dataset Biomarker types Biomarker subset Score transform Top biomarker R^2 P-Value FDR Reports

ShRNA Hairpin level scores

55k shRNA library (v2.4.6)

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98k shRNA library (v2.19.2)

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ShRNA Quality

Plot Table
shRNA ID Gene Symbol Seed1 Sequence Seed2 Sequence Gene Rsquared Seed1 Rsquared Seed2 Rsquared Seeds Rsquared Other Gene Rsquared Total Rsquared Alpha1 Alpha2 Beta Other Gene Symbol

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