AGBL3

ATP/GTP binding protein like 3

Dependent Cell Lines

CRISPR: 1/625

RNAi: 1/547

Dependency Score


Dependent Cell Line: A cell line is considered dependent if it has a probability of dependency greater than 0.5.
Dependency Score: Outcome from DEMETER2 or CERES. A lower score means that a gene is more likely to be dependent in a given cell line. A score of 0 is equivalent to a gene that is not essential whereas a score of -1 corresponds to the median of all common essential genes.


Enriched Lineages

CRISPR

Dependency Score (CERES)

1. Melanoma (9.7e-06)
2. Skin (5.6e-05)
3. Colorectal (6.2e-05)

RNAi

Dependency Score (DEMETER2)


Enriched lineages have p-values < 0.0005 shown in parentheses.


Expression & CN

TPM (log2)


Copy Number log2(relative to ploidy + 1)



Top Co-dependencies

CRISPR (Avana) Public 19Q3

GenePearson correlation
PlotSTRA80.37
PlotARF50.36
PlotTRPV50.34
PlotGALNTL50.33
PlotCPA10.32

Combined RNAi (Broad, Novartis, Marcotte)

GenePearson correlation
PlotMLC10.69
PlotCCR70.64
PlotITPR30.58
PlotPEX10.58
PlotUSP400.57

Target Tractability



Mutations

# of Cell lines



Description

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Mutation Public 19Q3

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Translocation

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Methylation (1kb upstream TSS) (7 134670258-134671258)

CpG Methylation

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  • Official symbol: AGBL3
  • Full name: ATP/GTP binding protein like 3
  • Location:
  • Also known as: MGC32955, CCP3
  • Entrez ID: 340351
  • Ensembl ID: ENSG00000146856

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