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Data availability

CRISPR-Cas9 screening results DepMap version 20Q1 (including raw data) and the genomic characterization of cancer cell lines (whole exome sequencing and RNA sequencing) used in this study are publicly available at depmap.org and also on figshare.

Code availability

Code to complete the analyses presented in this manuscript and generate corresponding figure panels and tables is publicly available on GitHub at https://github.com/ndharia-broad/peddep.